| to = duloxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.{{TCAdecrease25p3d}}| start = * '''Day 4:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine.{{StartAntidepressant}}| info = * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.{{review}}Safe target dose duloxetine = 60 mg
}}