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Imipramine-duloxetine

266 bytes removed, 13:45, 4 November 2015
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* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.{{stopImipramine}}
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* '''Day 4:''' simultaneously start administration of duloxetine in a normal dosage of 60 mg/day.
* '''Day 8:''' stop administration of imipramine and continue administration of duloxetine.
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{theorSS}}
* Duloxetine is a inhibitor of CYP2D6, which metabolizes imipramine.
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