* Gradually '''Before day 1:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day. * '''Day 1:''' reduce dosage of sertraline to 25 mg/day.

* '''Day 1:''' reduce sertraline to a dosage of 25 mg/day and simultaneously start administration of mianserine in a normal low dosage of 15-30 mg/day for one week.* '''Day 8:''' stop administration of sertraline and continue administration of just mianserineonly. }}