Changes

| stop =

* '''Before day 0:''' gradually reduce dosage of sertraline to a maximum of 50 mg/ day, when this dosage is > 50 mg/day.

| start =

* '''Day 1:''' simultaneously start administration of mianserine in a low dosage of 30 mg/day for one week.

* '''Day 8:''' stop administration of sertraline and continue administration of mianserine only. }}