| to = amitriptyline
| stop =
* '''Day 1:''' stop administration of vortioxetine.{{Stopvortioxetine}}
| start =
No wash-out period is needed.{{TCAincrease25p3d}}* '''Day 1:''' simultaneously start administration of amitriptyline in a dosage of 25 mg/day. | info =* '''Day 8:''' continue administration of amitriptyline in a dosage of 50 mg/day. {{TCAplasmalevelmonitoring}}* Start low, go slow.}}