Changes

* Administration '''Day 1-14:'''Gradually decrease the dosage of hypericum. * '''Day 15:''' stop administration of hypericum can be stopped abruptly.| start = * '''Day 115-1430:''' a wash-out period of one week at least two weeks is necessary.* '''Day 1531:''' start administration of amitriptyline in a dosage of 25 mg/day.* If necessary, increase dosage of amitriptyline to 50 mg/day.* Start low, go slow.

* Occurrence of the serotonin syndrome is theoretically possiblewithout the wash-out period.* Hypericum slows induces enzymes of the metabolism of amitriptyline via CYP3A4CYP P-450 type and P-gp. This effect may persist up to two weeks after stopping hypericum, so caution is necessary* Hypericum probably has MAO-inhibiting properties.}}