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# Switching from a drug with a short half life to a drug with a long half life is possibly more problematic. Plasma levels of the first drug decrease rapidly, while the second drug takes longer to reach a steady state plasma level. To overcome possible withdrawal/ relapse, the second drug should be started in a higher dose (approx. 50% of target dose) for about 4 days. Subsequently increase with 25% every 3-4 days.
# Warnings and advice are limited to the switch only. Specific drug properties can be found via the links on the right.
# Cytochrome P450 drug interactions between different antipsychotics are checked with the Flockart Flockhart interaction table. No inductors or inhibitors were found.
# Nearly all antipsychotics increase the risk of QT time prolongation with or without Torsade de Pointes (TDP). Under the heading ‘more information’ there is a recommendation, advising ECG monitoring. The SPC of sertindole contains the warning ECG monitoring required. No distinction has been made between drugs with and without TDP.
# See disclaimer.
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