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Created page with '{{Drugcombi | base = Lithium | add = Olanzapine | info = * Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects. * Olan...'
{{Drugcombi
| base = Lithium
| add = Olanzapine
| info =
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.
}}
| base = Lithium
| add = Olanzapine
| info =
* Lithium is eliminated by the kidney for about 95%. Changes in the rate of excretion can cause unwanted effects.
* Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
* This combination of drugs may have possible synergistic effects. However, this combination will also have additive side effects. Dose adaptation will be recommended for this combination.
| start =
* Start olanzapine according to the general dosing advice.
| cave =
* The concomitant administration of lithium with neuroleptic agents may increase the risk of extrapyramidal reactions and neurotoxicity.
}}
