* '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day.
* '''Day 8:''' stop administration of trazodone.
| start = * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.{{StartAgomelatine}}
| info =
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>
}}