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* '''Day 1:''' reduce dosage of bupropion to 150 mg/day.
* '''Day 8:''' stop administration of bupropion.
| start = * '''Day 1:''' simultaneously start administration of agomelatine in a dosage of 25 mg/day.* '''Day 8:''' only continue administration of agomelatine. If necessary, increase dosage of agomelatine to 50 mg/day.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102StartAgomelatine}}</ref>
}}
