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Fluoxetine-nortriptyline

54 bytes removed, 14:57, 20 February 2025
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* Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day. * When a dosage of 20 mg/day is reached, stop administration.{{stopFluoxetine1}}
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Caution is necessary for at least four weeks.
* '''Day 15:''' start administration of nortriptyline in a low dosage of 20 mg/day.* '''Day 8:''' increase dosage of nortriptyline to 30 25 mg/day.
* '''Day 15:''' increase dosage of nortriptyline to 50 mg/day.
* '''Day 20 and after:''' gradually increase dosage of nortriptyline if necessary.
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* {{TCAplasmalevelmonitoring}}* Fluoxetine slows and norfluoxetine slow the metabolism of nortriptyline via CYP2D6. {{longt1/2fluvox}}* Start low, go slow for nortriptyline. }}