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Paroxetine-moclobemide

772 bytes added, 22:13, 3 May 2009
Created page with '{{Drugswitch | from = paroxetine | to = moclobemide | stop = Depending on the condition of the patient, there are two scenarios possible: # Gradually reduce dosage of paroxeti...'
{{Drugswitch
| from = paroxetine
| to = moclobemide
| stop =
Depending on the condition of the patient, there are two scenarios possible:
# Gradually reduce dosage of paroxetine to a maximum of 20 mg/day, and then stop administration abruptly.
# Phase out paroxetine from 20 mg/day, to 10 mg/day for one week, and then stop administration abruptly.
| start =
* Both scenarios are followed by a wash-out period of one week.
* Then the administration of moclobemide can be started in normal dosage of 300 mg/day (2 times a day 150 mg).
| info =
* A switch from paroxetine to moclobemide is not obvious, given the necessary prolonged wash-out period in this case.
* Occurrence of serotonin syndrome is reported when a wash-out period (of one week) is not considered.}}
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