| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day. * '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration{{stopFluoxetine1}}
| start =
* A wash-out period is not necessary, but care is needed.* '''Day 15:''' start administration of vortioxetine the next day in a low dosage of 5 mg/day.* '''Day 15:''' increase dosage of vortioxetine to 10 mg/day.* '''Day 20 and after:''' gradually increase dosage of vortioxetine if necessary.| info = * Fluoxetine is a strong inhibitor and norfluoxetine slow the metabolism of vortioxetine via CYP2D6, which metabolizes vortioxetine. * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{longt1/2fluvox}}
}}