| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is > 10 mg/day. * '''Day 1:''' when a dosage of 10 mg/day is reached, stop administration{{stopFluoxetine1}}
| start =
* A wash-out period is not necessary, but care is needed.* '''Day 15:''' start administration of vortioxetine in a low dosage of 10 5 mg/day.| info =* Fluoxetine is a strong inhibitor '''Day 15:''' increase dosage of CYP2D6, which metabolizes vortioxetineto 10 mg/day. * Occurrence '''Day 20 and after:''' gradually increase dosage of serotonin syndrome is theoretically possible, so caution is vortioxetine if necessary.| info = * Patients could be directly switched from a SSRI or a SNRI to vortioxetine 10 mg/day. One week after intiation with vortioxetine, Fluoxetine and norfluoxetine slow the dosage could be increased from 10 mg/day to 20 mg/day.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/25087600 Montgomery SA et al. A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course metabolism of selective serotonin reuptake inhibitor or serotonin-noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatinevia CYP2D6. Hum Psychopharmacol. 2014 Sep;29(5):470-82.]<{{longt1/ref> 2fluvox}}
}}