Changes

* '''Day 8:''' stop administration of vortioxetine.

| start =

* A wash-out period of 2 weeks is necessary.

* '''Day 22:''' start administration of fluoxetine in a normal dosage of 20 mg/day.

| info =

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.

* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}