Changes

* A wash-out period of 2 weeks is necessary, because of CYP2D6-inhibition.

* '''Day 22:''' start administration of fluoxetine in a normal dosage of 20 mg/day.

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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.

* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}