| stop = {{downparoxStopSSRI,SNRI}}

* A wash-out period is not necessary'''Day 1:''' start administration of vortioxetine in a low dosage of 5 mg/day.* '''Day 158:''' start administration increase dosage of vortioxetine in to a normal dosage of 10 mg/day.

* Paroxetine is a strong inhibitor slows the metabolism of CYP2D6, which metabolizes vortioxetine. * Occurrence via inhibition of serotonin syndrome is theoretically possible, so caution is necessaryCYP2D6.