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Created page with '{{Drugswitch | from = venlafaxine | to = imipramine | stop = * '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day. * '''Day 1:''' reduce a dosage o...'
{{Drugswitch
| from = venlafaxine
| to = imipramine
| stop =
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of venlafaxine and continue administration of imipramine in a dosage of 50 mg/day.
| info =
* “Start low, go slow” for imipramine, and caution with this switch is necessary.
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes imipramine.}}
| from = venlafaxine
| to = imipramine
| stop =
* '''Day 0:''' gradually reduce dosage of venlafaxine to a maximum of 75 mg/ day.
* '''Day 1:''' reduce a dosage of 75 mg/day to 37,5 mg/day.
| start =
* '''Day 1:''' simultaneously start administration of imipramine in a low dosage of 25 mg/day.
* '''Day 8:''' stop administration of venlafaxine and continue administration of imipramine in a dosage of 50 mg/day.
| info =
* “Start low, go slow” for imipramine, and caution with this switch is necessary.
* Venlafaxine is a weak inhibitor of CYP2D6, which metabolizes imipramine.}}
