* '''Day 159:''' start agomelatine in a dosage of 25 mg/day.* '''Day 2216:''' if necessary, gradually increase dosage of agomelatine to target dose.<ref name="agoswitch"> {{Pubmed|20196187|McAllister-Williams RH et al. The use of antidepressants in clinical practice: focus on agomelatine. Hum Psychopharmacol. 2010 Mar 1;25(2):95-102}}</ref>