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Fluvoxamine-amitriptyline

256 bytes removed, 13:58, 28 October 2015

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* '''Before day 1:''' gradually reduce dosage of fluvoxamine to a maximum of 100 mg/day when the dosage is > 100 mg/day.

* '''Day 1:''' reduce dosage of fluvoxamine to a maximum of 50 mg/day.

* '''Day 8:''' stop administration of fluvoxamine

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* '''Day 1:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg/day.

* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize amitriptyline.

* {{theorSS}}

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