| to = vortioxetine
| stop =
* '''Before day 1:''' gradually reduce dosage of imipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of imipramine to 50 mg/day.* '''Day 3:''' reduce dosage of imipramine to 25 mg/day.* '''Day 8:''' stop administration of imipramine.{{stopImipramine}}
| start =
* A wash-out period is not necessary.
* '''Day 89:''' start administration of vortioxetine in a low dosage of 10 mg/day.
| info =
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.{{reviewtheorSS}}
}}