Difference between revisions of "Dosulepine-fluoxetine"

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{{Drugswitch  
 
{{Drugswitch  
| from = dosulepine  
+
| from = dosulepine
| to = fluoxetine  
+
| to = fluoxetine
 
| stop =  
 
| stop =  
* '''Before day 1:''' gradually reduce dosage of dosulepine to a maximum of 75 mg/day.
+
{{TCAdecrease25p3d}}
* '''Day 1:''' reduce dosage of dosulepine to 50 mg/day.
 
* '''Day 3:''' reduce dosage of dosulepine to 25 mg/day.
 
* '''Day 7:''' stop dosulepine
 
 
| start =  
 
| start =  
* '''Day 8:''' start administration of fluoxetine in a normal dosage of 20 mg/day.
+
* '''Day 6 and after''': At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose.
 +
* ''' After 3 weeks:''' If necessary, gradually increase dosage of fluoxetine.
 +
 
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* Safe target dose fluoxetine = 20 mg
* Fluoxetine is a strong inhibitor of CYP2D6, which metabolizes dosulepine.  
+
* Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolize dosulepine.
{{review}}
+
}}
}}
 

Latest revision as of 12:18, 8 March 2024

dosulepin
Type antidepressant
Group TCA
links
ATC-code N06AA16
PubChem 13473
PubMed dosulepin
Kompas (Dutch) dosulepin
Wikipedia dosulepin
Fluoxetine
Type Antidepressant
Group SSRI
links
Medscape Fluoxetine
PubChem 3386
PubMed Fluoxetine
Kompas (Dutch) Fluoxetine
Wikipedia Fluoxetine

Switch medication from dosulepine to fluoxetine.[1] [2]

Nietinrijdenbord.png Stop dosulepine
  • Day 1: Decrease with about 25% of the original dose per 3 days.
Eenrichtingbord.png Start fluoxetine
  • Day 6 and after: At approximately 50-25% of the original TCA dosering start fluoxetine at 100% of the target dose.
  • After 3 weeks: If necessary, gradually increase dosage of fluoxetine.
Infobord.png More information
  • Safe target dose fluoxetine = 20 mg
  • Fluoxetine and norfluoxetine are inhibitors of CYP2D6 (strong) which metabolize dosulepine.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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