Difference between revisions of "Aripiprazole LA-Partial agonist"

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* the T<sub>1/2</sub> of aripiprazole depot is 46.5 days after administration of 400 mg and approximately 29.9 days after adminstration of 300 mg.
  
 
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Revision as of 14:45, 8 March 2024

Aripiprazole
long acting
Type Antipsychotic
Group Atypical AP
Other use moodstabilizer
links
Medscape Aripiprazole
EMEA abilify
PubChem 60975
PubMed Aripiprazole
Kompas (Dutch) Aripiprazole
Wikipedia Aripiprazole
Partial agonists

Aripiprazole
Brexpiprazole
Cariprazine

Switch medication from Aripiprazole LA to Partial agonist.[1] [2]
Partial agonist is a collection of antipsychotic drugs having similar properties with respect to switching. A switch to member of the 'partial agonist' group from anotherdrug should be read as partial agonist-anotherdrug. Similarly, a switch from a member of the 'partial agonist' group to anotherdrug should be read as anotherdrug-partial agonist.

Nietinrijdenbord.png Stop Aripiprazole LA
  • Day 1: Last depot injection
Eenrichtingbord.png Start Partial agonist
  • t= 0 Start dosing 25% of the target dose on the day you normally would have injected the former depot.
  • t= 1 x T1/2 of depot approx. 50% of target dose
  • t= 2 x T1/2 of depot approx. 75% of target dose
  • t= 3 x T1/2 of depot approx. 100% of target dose
  • See 'more information' for the T1/2 of this depot
Infobord.png More information
  • More information you'll find in the summary of product characteristics (SPC) of aripiprazole depot injection. [3]
  • the T1/2 of aripiprazole depot is 46.5 days after administration of 400 mg and approximately 29.9 days after adminstration of 300 mg.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
  3. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002755/WC500156111.pdf SPC of the European Medicines Agency on aripiprazole depot
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