Difference between revisions of "Fluphenazine LA-Rest AP"
From Psychiatrienet
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{{Drugswitch | {{Drugswitch | ||
| from = Fluphenazine_LA | | from = Fluphenazine_LA | ||
− | | to = Rest AP | + | | to = Rest AP<ref> A. Risselada, Switchen van en naar depotantipsychotica - een update; Psyfar, june 2022 nummer 2 </ref> |
| stop = {{Lastinjection}} | | stop = {{Lastinjection}} | ||
− | | start = {{ | + | | start = {{StartOral afterDepot}} |
| info = {{caveQT}} | | info = {{caveQT}} | ||
− | + | * the T<sub>1/2</sub> of fluphenazine depot is approximately 7-10 days.<ref> SmPC Anatensol Bristol-Myers Squibb B.V.</ref> | |
+ | |||
}} | }} |
Revision as of 14:58, 8 March 2024
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{{:Rest AP[1] }} |
Switch medication from Fluphenazine_LA to Rest AP[1].[2] [3]
- Day 1: Last depot injection
Start Rest AP[1]
- t= 0 Start dosing 25% of the target dose on the day you normally would have injected the former depot.
- t= 1 x T1/2 of depot approx. 50% of target dose
- t= 2 x T1/2 of depot approx. 75% of target dose
- t= 3 x T1/2 of depot approx. 100% of target dose
- See 'more information' for the T1/2 of this depot
- During this switch you could monitor ECG, especially in patients prone to QT-conduction problems.
- There is a possibility of QT interval prolongation.[4]
- the T1/2 of fluphenazine depot is approximately 7-10 days.[5]
- ↑ A. Risselada, Switchen van en naar depotantipsychotica - een update; Psyfar, june 2022 nummer 2
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ Stöllberger C, Huber JO, Finsterer J, Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol. 2005 Sep;20(5):243-51.
- ↑ SmPC Anatensol Bristol-Myers Squibb B.V.
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[[Category:SwitchRest AP[1]]]