* '''Day 0Before day 1:''' gradually reduce dosage of If paroxetine to a maximum of 20 mg/day when this dosage dose is > 20 mgabove 20mg/day. * '''Day 1:''' gradually reduce dosage of paroxetine dose to a maximum of 10 20 mg/day. * '''Day 81:''' reduce dosage Decrease with about 25% of paroxetine to 5 mg/day.original dose every 3-4 days

Caution is necessary.* '''Day 81:''' simultaneously start administration of amitriptyline in a low dosage of 25 mg25mg/day. * '''Day 15Stop paroxetine:''' stop administration of paroxetine and only continue administration increase dosage of amitriptyline in to a dosage of 50-100 mg/day.* Start low, go slow!

* Paroxetine slows the metabolism of amitriptyline via CYP2D6inhibition. * {{SSCYPinh}}* {{TCAplasmalevelmonitoring}}}}