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* '''Day 0Before day 1:''' If paroxetine dose is above 20mg/day gradually reduce dosage of paroxetine dose to a maximum of 20 mg/day, when this dosage is > 20 mg/day.* '''Day 1:''' reduce dosage Decrease with about 25% of paroxetine to a maximum of 10 mg/day.original dose every 3-4 days
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* '''Day 1:''' simultaneously start administration of bupropion is in a normal dosage of 150 mg/day. * '''Day 8:''' stop paroxetine and continue administration of if necessary increase bupropion in a dosage of 150 to 300 mg/day.| info =* '''Day 28:''' if necessary increase Its possible to start bupropion before day 1, while reducing the dose of paroxetine to 300 mg20mg/day.* Bupropion is a strong CYP2D6 inhibitor
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