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* '''Day 1:''' simultaneously start administration of bupropion is in a normal dosage of 150 mg/day. * '''Day 158:''' if necessary increase bupropion dosage to 300 mg/day.
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* An extra reduction week Its possible to start bupropion before day 1, while reducing the dose of paroxetine 2,5 mgto 20mg/day sometimes is necessary.* Low doses of paroxetine can be given by Bupropion is a paroxetine-solution.{{review}}strong CYP2D6 inhibitor
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