| stop = {{stopVortioxetineStopSSRI,SNRI}}| start = * ''' Day 8-14: ''' a wash-out period of 1 week is necessary, because of CYP2D6-inhibition and serotonergic actions. <ref name="vortiswitch"> {{Pubmed|24570588 |Katona et al. New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder. 2014 2014 Feb 19;10:349-54}}</ref> <ref name="informatorium">{{KNMP|vortioxetineStartAntidepressant}}</ref>* '''Day 15:''' Start sertraline in a normal dosage of 50 mg/day. | info = * {{theorSS}}Safe target dose sertraline = 100 mg* Sertraline is a strong inhibitor of CYP2D6, which metabolizes vortioxetine. }}