| to = trazodone
| stop =
* Gradually reduce dosage of bupropion to a maximum of 150 mg/day. * When a dosage of 150 mg/day is reached, stop administration.{{stopBupropion}}| start = * Start trazodone the same day in a normal dosage of 100-150 mg/day.{{StartAntidepressant}}| info = * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. Safe target dose trazodone = 150 mg
* Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
}}