* Gradually reduce dosage of bupropion to a maximum of 150 mg/day. * When a dosage of 150 mg/day is reached, stop administration.{{stopBupropion}}| start = {{StartAntidepressant}}* A wash-out period of one week is recommended. | info =* Start Safe target dose trazodone the next day in a normal dosage of = 150 mg/day.| info = * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. * Bupropion possibly slows slow the metabolismof metabolism of trazodone by CYP2D6.}}