Changes

* A wash'''Day 7 and after''': At approximately 50-out period is not necessary, but care is needed25% of the original vortioxetine dose start paroxetine at 50% of the target dose.* '''Day 814:''' start administration of Increase paroxetine in a normal dosage to 100% of 10-20 mg/day.the target dose 

* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.Safe target dose paroxetine = 20 mg* Paroxetine paroxetine is a strong CYP2D6 inhibitor of CYP2D6, which metabolizes metabolize vortioxetine. }}