Difference between revisions of "Clomipramine-fluvoxamine"
From Psychiatrienet
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| − | + | * Fluvoxamine is an inhibitor of CYP2C19, which metabolize clomipramine. | |
| − | * Fluvoxamine is an inhibitor of | + | * Safe target dose fluvoxamine = 100 mg |
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Latest revision as of 16:06, 20 February 2025
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Switch medication from clomipramine to fluvoxamine[1][2]
Stop clomipramine - Day 1: Decrease with about 25% of the original dose per 3 days.
Start fluvoxamine- Day 6: At approximately 50-25% of the original drug dose start fluvoxamine at 50% of the target dose.
- Day 12: Increase dosage of fluvoxamine to 100% of the target dose.
- Day 17: Increase dosage of fluvoxamine if necessary.
More information- Fluvoxamine is an inhibitor of CYP2C19, which metabolize clomipramine.
- Safe target dose fluvoxamine = 100 mg
- Jump up ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- Jump up ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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