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Clomipramine-fluvoxamine

467 bytes removed, 20 February
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* '''Before day 0:''' gradually reduce dosage of clomipramine to a maximum of 75 mg/day.* '''Day 1:''' reduce dosage of clomipramine to 50 mg/day.* '''Day 3:''' reduce dosage of clomipramine to 25 mg/day.{{TCAdecrease25p3d}}
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* '''Day 1:''' simultaneously start administration of fluvoxamine in a normal dosage of 50 mg/day.* '''Day 8:''' stop administration of clomipramine and continue administration of fluvoxamine in a dosage of 50-100 mg/day.{{StartfluvoxIA}}
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* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.* Fluvoxamine is an inhibitor of CYP1A2, CYP2C19 and CYP3A4 (moderate), which metabolize clomipramine.* Safe target dose fluvoxamine = 100 mg}}