Difference between revisions of "Fenelzine-vortioxetine"
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| + | {{14dWashout}}<ref>van den Eynde et al. The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression CNS Spectr 2023;28(4):427-440. doi: 10.1017/S1092852922000906.</ref> | ||
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| − | * '''Day | + | * '''Day 23:''' start administration of vortioxetine in a normal dosage of 10 mg/day. <ref name="informatorium">{{KNMP|fenel}}</ref> |
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Switch medication from fenelzine to vortioxetine[1][2]
Stop fenelzine - Day 1: decrease the original dose with about 25% every 3 days.
- Day 9: stop administration of fenelzine.
- Stop and wait 14 days for washout[3]
Start vortioxetine- A wash-out period of two weeks is necessary.
- Day 23: start administration of vortioxetine in a normal dosage of 10 mg/day. [4]
Cave- Occurrence of the serotonin syndrome is possible without a wash-out period.
More information- After the last dose of tranylcypromine and/or fenelzine it takes about 14 days to restore the activity of the MAO enzymes
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
- ↑ van den Eynde et al. The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression CNS Spectr 2023;28(4):427-440. doi: 10.1017/S1092852922000906.
- ↑ KNMP; Informatorium Medicamentorum 2023; Monografie "fenel" (Dutch)
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