Difference between revisions of "Paroxetine-citalopram"

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{{Drugswitch  
 
{{Drugswitch  
 
| from = paroxetine  
 
| from = paroxetine  
| to = nortriptyline
+
| to = citalopram
 
| stop =  
 
| stop =  
* '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.  
+
* Gradually reduce dosage of paroxetine to a maximum of 20 mg/day, when this dosage is > 20 mg/day.  
* '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day.
+
* When a dosage of 20 mg/day is reached, stop administration.
* '''Day 8:''' reduce dosage of paroxetine to 5 mg/day.
 
 
| start =  
 
| start =  
Caution is necessary.
+
* No wash-out period is needed.  
* '''Day 8:''' simultaneously start administration of nortriptyline in a low dosage of 25 mg/day.  
+
* Start citalopram/escitalopram the next day in normal dosage of 20 mg/day, resp. 10 mg/day.}}
* '''Day 15:''' stop administration of paroxetine and only continue administration of noritriptyline in a dosage of 50 mg/day.
 
* "Start low, go slow" is not required, but caution is necessary!
 
| info =
 
* Paroxetine slows the metabolism of nortriptyline via CYP2D6. }}
 

Revision as of 09:42, 7 May 2009

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Citalopram
Type Antidepressant
Group SSRI
links
ATC-code N06AB04
Medscape Citalopram
PubChem 2771
PubMed Citalopram
Kompas (Dutch) citalopram
Wikipedia citalopram

Switch medication from paroxetine to citalopram.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Gradually reduce dosage of paroxetine to a maximum of 20 mg/day, when this dosage is > 20 mg/day.
  • When a dosage of 20 mg/day is reached, stop administration.
Eenrichtingbord.png Start citalopram
  • No wash-out period is needed.
  • Start citalopram/escitalopram the next day in normal dosage of 20 mg/day, resp. 10 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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