Difference between revisions of "Tranylcypromine-amitriptyline"

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* '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day.
 
* '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day.
 
| info =  
 
| info =  
* Occurence of the serotonin syndrome is theoretically possible.
+
* Occurence of the serotonin syndrome is possible without a wash-out period.
 
* The wash-out period is necessary for the MAO enzymes to restore their function.}}
 
* The wash-out period is necessary for the MAO enzymes to restore their function.}}

Revision as of 13:52, 8 May 2009

Tranylcypromine
Type Antidepressant
Group MAO-I
links
Medscape Tranylcypromine
PubChem 5530
PubMed Tranylcypromine
Kompas (Dutch) Tranylcypromine
Wikipedia Tranylcypromine
Amitriptyline
Type Antidepressant
Group TCA
links
ATC-code N06AA09
Medscape Amitriptyline
PubChem 2160
PubMed Amitriptyline
Kompas (Dutch) Amitriptyline
Wikipedia Amitriptyline

Switch medication from tranylcypromine to amitriptyline.[1] [2]

Nietinrijdenbord.png Stop tranylcypromine
  • Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
  • When a dosage of 10 mg/day is reached, stop administration.
Eenrichtingbord.png Start amitriptyline
  • Day 1-14: a wash-out period of two weeks is necessary.
  • Day 15: start amitriptyline after this period in a low dosage of 25-50 mg/day.
Infobord.png More information
  • Occurence of the serotonin syndrome is possible without a wash-out period.
  • The wash-out period is necessary for the MAO enzymes to restore their function.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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