Difference between revisions of "Tranylcypromine-amitriptyline"
From Psychiatrienet
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* '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day. | * '''Day 15:''' start amitriptyline after this period in a low dosage of 25-50 mg/day. | ||
| info = | | info = | ||
| − | * Occurence of the serotonin syndrome is | + | * Occurence of the serotonin syndrome is possible without a wash-out period. |
* The wash-out period is necessary for the MAO enzymes to restore their function.}} | * The wash-out period is necessary for the MAO enzymes to restore their function.}} | ||
Revision as of 13:52, 8 May 2009
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Switch medication from tranylcypromine to amitriptyline.[1] [2]
Stop tranylcypromine - Gradually decrease the dosage of tranylcypromine with 10-20 mg/week.
- When a dosage of 10 mg/day is reached, stop administration.
Start amitriptyline- Day 1-14: a wash-out period of two weeks is necessary.
- Day 15: start amitriptyline after this period in a low dosage of 25-50 mg/day.
More information- Occurence of the serotonin syndrome is possible without a wash-out period.
- The wash-out period is necessary for the MAO enzymes to restore their function.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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