Difference between revisions of "Trazodone-sertraline"

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| stop =  
 
| stop =  
 
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
 
* '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.  
* '''Day 1:''' reduce dosage of trazodone to 75 mg/day.
+
* '''Day 1:''' reduce dosage of trazodone to 75-100 mg/day.
 
* '''Day 8:''' stop administration of trazodone.
 
* '''Day 8:''' stop administration of trazodone.
 +
* '''Day 8-13:''' wash-out period
 
| start =  
 
| start =  
* A wash-out period is not necessary, but care is needed.
+
* '''Day 14:''' start administration of sertraline in a normal dosage of 50 mg/day.
* '''Day 8:''' start administration of sertraline in a normal dosage of 50 mg/day.
 
 
| info =  
 
| info =  
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
+
* Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.
* Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.}}
 

Revision as of 12:40, 10 July 2009

{{ Drugswitch | from = trazodone | to = sertraline | stop =

  • Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
  • Day 1: reduce dosage of trazodone to 75-100 mg/day.
  • Day 8: stop administration of trazodone.
  • Day 8-13: wash-out period

| start =

  • Day 14: start administration of sertraline in a normal dosage of 50 mg/day.

| info =

  • Sertraline dose-dependently inhibits CYP2D6, which metabolizes trazodone.