Difference between revisions of "Trazodone-venlafaxine"
From Psychiatrienet
| Line 3: | Line 3: | ||
| to = venlafaxine | | to = venlafaxine | ||
| stop = | | stop = | ||
| − | * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of | + | * '''Before day 0:''' gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day. |
| − | * '''Day 1:''' stop administration of trazodone. | + | * '''Day 1:''' reduce dosage of trazodone to 75 mg/day. |
| + | * '''Day 8:''' stop administration of trazodone. | ||
| start = | | start = | ||
| − | + | * '''Day 8-14:''' a wash-out period of one week is necessary. | |
| − | * '''Day | + | * '''Day 15:''' start administration of venlafaxine in a dosage 37,5 mg or 75 mg (slow release) |
| + | * If necessary, increase dosage of tranylcypromine. | ||
| info = | | info = | ||
| − | * Occurrence of serotonin syndrome is theoretically possible, so | + | * Occurrence of the serotonin syndrome is theoretically possible, so care is needed. |
* The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} | * The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given. }} | ||
Revision as of 12:49, 10 July 2009
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Switch medication from trazodone to venlafaxine.[1] [2]
Stop trazodone - Before day 0: gradually reduce dosage of trazodone to a maximum of 150 mg/day, when this dosage is > 150 mg/day.
- Day 1: reduce dosage of trazodone to 75 mg/day.
- Day 8: stop administration of trazodone.
Start venlafaxine- Day 8-14: a wash-out period of one week is necessary.
- Day 15: start administration of venlafaxine in a dosage 37,5 mg or 75 mg (slow release)
- If necessary, increase dosage of tranylcypromine.
More information- Occurrence of the serotonin syndrome is theoretically possible, so care is needed.
- The content of trazodone in the tablet, for example 100 mg or 150 mg, determines which exact doses are given.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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