Difference between revisions of "Bupropion-trazodone"
From Psychiatrienet
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* Start trazodone the same day in a normal dosage of 100-150 mg/day. | * Start trazodone the same day in a normal dosage of 100-150 mg/day. | ||
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− | * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. | + | * Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually. |
− | * Bupropion | + | * Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6. |
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Revision as of 16:08, 20 July 2009
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Switch medication from bupropion to trazodone.[1] [2]
- Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
- When a dosage of 150 mg/day is reached, stop administration.
- Start trazodone the same day in a normal dosage of 100-150 mg/day.
- Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
- Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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