Difference between revisions of "Bupropion-trazodone"

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* Start trazodone the same day in a normal dosage of 100-150 mg/day.
 
* Start trazodone the same day in a normal dosage of 100-150 mg/day.
 
| info =   
 
| info =   
* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.  
+
* Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
* Bupropion possibly slows the metabolism of trazodone by CYP2D6.
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* Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
 
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Revision as of 16:08, 20 July 2009

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from bupropion to trazodone.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Gradually reduce dosage of bupropion to a maximum of 150 mg/day.
  • When a dosage of 150 mg/day is reached, stop administration.
Eenrichtingbord.png Start trazodone
  • Start trazodone the same day in a normal dosage of 100-150 mg/day.
Infobord.png More information
  • Bupropion and its metabolites have long elimination times, so plasma concentrations will reduce gradually.
  • Bupropion and its metabolites slow the metabolism of trazodone by CYP2D6.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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