Difference between revisions of "Paroxetine-trazodone"

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| start =  
 
| start =  
 
*  '''Day 9:''' {{startTrazo}}  
 
*  '''Day 9:''' {{startTrazo}}  
 
+
* If necessary, increase the dosage of trazodone every 3-4 days to a maximum of 400 mg/day.
* If necessary, increase the dosage of trazodone to a maximum of 400 mg/day.
 
 
| info =  
 
| info =  
 
* Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.}}
 
* Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.}}

Revision as of 08:19, 21 July 2009

paroxetine
Type Antidepressant
Group SSRI
links
Medscape paroxetine
PubChem 43815
PubMed paroxetine
Kompas (Dutch) paroxetine
Wikipedia paroxetine
Trazodone
Type Antidepressant
Group other
links
Medscape Trazodone
PubChem 5533
PubMed Trazodone
Kompas (Dutch) Trazodone
Wikipedia Trazodone

Switch medication from paroxetine to trazodone.[1] [2]

Nietinrijdenbord.png Stop paroxetine
  • Before day 0: gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
  • Day 1: reduce dosage of paroxetine to 10 mg/day.
  • Day 8: stop administration of paroxetine.
Eenrichtingbord.png Start trazodone
  • Day 9: start trazodone in dosage of 100-150 mg/day.
  • If necessary, increase the dosage of trazodone every 3-4 days to a maximum of 400 mg/day.
Infobord.png More information
  • Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.
  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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