Difference between revisions of "Paroxetine-trazodone"
From Psychiatrienet
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* '''Day 9:''' {{startTrazo}} | * '''Day 9:''' {{startTrazo}} | ||
| − | + | * If necessary, increase the dosage of trazodone every 3-4 days to a maximum of 400 mg/day. | |
| − | * If necessary, increase the dosage of trazodone to a maximum of 400 mg/day. | ||
| info = | | info = | ||
* Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.}} | * Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.}} | ||
Revision as of 08:19, 21 July 2009
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Switch medication from paroxetine to trazodone.[1] [2]
Stop paroxetine - Before day 0: gradually reduce dosage of paroxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: stop administration of paroxetine.
Start trazodone- Day 9: start trazodone in dosage of 100-150 mg/day.
- If necessary, increase the dosage of trazodone every 3-4 days to a maximum of 400 mg/day.
More information- Paroxetine slows the metabolism of trazodone via CYP2D6, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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