Difference between revisions of "Bupropion-moclobemide"

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(Created page with '{{Drugswitch | from = bupropion | to = moclobemide | stop = * Gradually reduce dosage of bupropion to a maximum of 150 mg/ day. * When a dosage of 150 mg/day is reached, sto...')
 
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* '''Day 1-7:''' wash-out period of one week is necessary.  
 
* '''Day 1-7:''' wash-out period of one week is necessary.  
 
* '''Day 8:''' start normal dosage of moclobemide after this week, 300 mg/day.
 
* '''Day 8:''' start normal dosage of moclobemide after this week, 300 mg/day.
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* By considering a wash-out period of one week (5 times the elimination time of bupropion and its metabolites) it is assured that all bupropion has left the body and no drug interactions occur. }}
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Revision as of 07:47, 23 July 2009

Bupropion
Type Antidepressant
Group other
links
ATC-code N06AX12
Medscape Bupropion
PubChem 444
PubMed Bupropion
Kompas (Dutch) Bupropion
Wikipedia Bupropion
Moclobemide
Type Antidepressant
Group MAO-I
links
Medscape Moclobemide
PubChem 4235
PubMed Moclobemide
Kompas (Dutch) Moclobemide
Wikipedia Moclobemide

Switch medication from bupropion to moclobemide.[1] [2]

Nietinrijdenbord.png Stop bupropion
  • Gradually reduce dosage of bupropion to a maximum of 150 mg/ day.
  • When a dosage of 150 mg/day is reached, stop administration.
Eenrichtingbord.png Start moclobemide
  • Day 1-7: wash-out period of one week is necessary.
  • Day 8: start normal dosage of moclobemide after this week, 300 mg/day.


  1. Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
  2. Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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