Difference between revisions of "Paroxetine-dosulepine"
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(Created page with '{{Drugswitch | from = paroxetine | to = dosulepine | stop = * '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. *...') |
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* '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. | * '''Day 0:''' gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day. | ||
* '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. | * '''Day 1:''' reduce dosage of paroxetine to a maximum of 10 mg/day. | ||
| − | * '''Day 8:''' | + | * '''Day 8:''' stop dosage of paroxetine. |
| start = | | start = | ||
Caution is necessary. | Caution is necessary. | ||
| − | * '''Day 8:''' | + | * '''Day 8:''' start administration of dosulepine in a low dosage of 50 mg/day. |
| − | * '''Day 15:''' | + | * '''Day 15:''' increase administration of dosulepine. |
| − | |||
| info = | | info = | ||
* Paroxetine possibly slows the metabolism of dosulepine via CYP2D6. }} | * Paroxetine possibly slows the metabolism of dosulepine via CYP2D6. }} | ||
Revision as of 07:55, 24 July 2009
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Switch medication from paroxetine to dosulepine.[1] [2]
Stop paroxetine - Day 0: gradually reduce dosage of paroxetine to a maximum of 20 mg/day when this dosage is > 20 mg/day.
- Day 1: reduce dosage of paroxetine to a maximum of 10 mg/day.
- Day 8: stop dosage of paroxetine.
Start dosulepineCaution is necessary.
- Day 8: start administration of dosulepine in a low dosage of 50 mg/day.
- Day 15: increase administration of dosulepine.
More information- Paroxetine possibly slows the metabolism of dosulepine via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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