Difference between revisions of "Paroxetine-nortriptyline"
From Psychiatrienet
| Line 5: | Line 5: | ||
{{downparox}} | {{downparox}} | ||
| start = | | start = | ||
| − | * '''Day | + | * '''Day 15:''' start administration of nortriptyline in a low dosage of 25 mg/day. |
| − | * '''Day | + | * '''Day 22:''' continue nortriptyline in a dosage of 50 mg/day. |
| − | |||
| info = Paroxetine slows the metabolism of nortriptyline via CYP2D6. }} | | info = Paroxetine slows the metabolism of nortriptyline via CYP2D6. }} | ||
Revision as of 12:26, 27 July 2009
| ||||||||||||||||||||||
| ||||||||||||||||||||||
Switch medication from paroxetine to nortriptyline.[1] [2]
Stop paroxetine - Day -7: reduce dosage of paroxetine to 20 mg/day, if this dosage is > 20 mg/day.
- Day 0: dosage of paroxetine is 20 mg/day.
- Day 1: reduce dosage of paroxetine to 10 mg/day.
- Day 8: reduce dosage of paroxetine to 5 mg/day.
- Day 15: stop administration of paroxetine.
Start nortriptyline- Day 15: start administration of nortriptyline in a low dosage of 25 mg/day.
- Day 22: continue nortriptyline in a dosage of 50 mg/day.
More informationParoxetine slows the metabolism of nortriptyline via CYP2D6.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
The editors of psychiatrienet.nl take the greatest care to provide up-to-date and accurate information on this site. Nevertheless, mistakes and omissions cannot be entirely excluded. No rights devolve from the information provided. The editors and other providers of information to this site accept no responsibility for the content of this site or for the information provided therein; neither do they accept responsibility for possible damages which may derive from the use of the information on this site or from the linked sites. The editorial board accepts no responsibility for the content of the (linked) sites, for access to them, or for the products and services on these sites, nor for the occurrence of errors, viruses, and/or disruptions in service.
