Difference between revisions of "Maprotiline-paroxetine"
From Psychiatrienet
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* '''Day 3:''' reduce dosage of maprotiline to 25 mg/day. | * '''Day 3:''' reduce dosage of maprotiline to 25 mg/day. | ||
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| − | * '''Day | + | * '''Day 3:''' simultaneously start administration of paroxetine in a normal dosage of 20 mg/day. |
* '''Day 8:''' stop administration of maprotiline and continue administration of paroxetine. | * '''Day 8:''' stop administration of maprotiline and continue administration of paroxetine. | ||
| info = | | info = | ||
* Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | * Occurrence of serotonin syndrome is theoretically possible, so caution is necessary. | ||
* Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline. }} | * Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline. }} | ||
Revision as of 12:57, 31 July 2009
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Switch medication from maprotiline to paroxetine.[1] [2]
Stop maprotiline - Before day 0: gradually reduce dosage of maprotiline to a maximum of 75 mg/day.
- Day 1: reduce dosage of maprotiline to 50 mg/day.
- Day 3: reduce dosage of maprotiline to 25 mg/day.
Start paroxetine- Day 3: simultaneously start administration of paroxetine in a normal dosage of 20 mg/day.
- Day 8: stop administration of maprotiline and continue administration of paroxetine.
More information- Occurrence of serotonin syndrome is theoretically possible, so caution is necessary.
- Paroxetine is a strong inhibitor of CYP2D6, which metabolizes maprotiline.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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