Difference between revisions of "Fluoxetine-paroxetine"
From Psychiatrienet
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No wash-out period is needed. | No wash-out period is needed. | ||
| − | * '''Day 1:''' start paroxetine the next day in low dosage of 10 mg/day | + | * '''Day 1:''' start paroxetine the next day in low dosage of 10 mg/day. |
| − | * '''Day | + | * '''Day 21:''' increase dosage of paroxetine to normal, 20 mg/day. |
| info = | | info = | ||
| − | * Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary. }} | + | * Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary. |
| + | * {{theorSS}} | ||
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Revision as of 08:46, 3 August 2009
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Switch medication from fluoxetine to paroxetine.[1] [2]
Stop fluoxetine - Gradually reduce dosage of fluoxetine to a maximum of 20 mg/ day, when this dosage is > 20 mg/day.
- When a dosage of 20 mg/day is reached, stop administration.
Start paroxetineNo wash-out period is needed.
- Day 1: start paroxetine the next day in low dosage of 10 mg/day.
- Day 21: increase dosage of paroxetine to normal, 20 mg/day.
More information- Fluoxetine has a very long elimination time; phasing out fluoxetine is therefore not necessary.
- Occurrence of the serotonin syndrome is not likely, but theoretically possible, so caution is necessary.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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