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| to = imipramine
| stop =
* '''Day 0Before day 1:''' gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
* '''Day 1:''' reduce a dosage of 60 mg/day to 30 mg/day.
| start =
No wash-out period is needed.
* '''Day 1:''' simultaneously start administration of imipramine in a dosage of 25 mg/day.
* '''Day 8:''' stop administration of mianserine and continue administration of imipramine only in a dosage of 50 mg/day. If necessary, increase dosage of amitriptylineimipramine.
* Start low, go slow.}}