Switch medication from mianserine to imipramine.
- Before day 1: gradually reduce dosage of mianserine to a maximum of 60 mg/ day.
- Day 1: reduce a dosage of 60 mg/day to 30 mg/day.
No wash-out period is needed.
- Day 1: simultaneously start administration of imipramine in a dosage of 25 mg/day.
- Day 8: stop administration of mianserine and continue administration of imipramine only in a dosage of 50 mg/day. If necessary, increase dosage of imipramine.
- Start low, go slow.
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