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No wash-out period is needed.
* '''Day 1:''' simultaneously start administration of imipramine in a dosage of 25 mg/day.
* '''Day 8:''' stop administration of mianserine and continue administration of imipramine only in a dosage of 50 mg/day. If necessary, increase dosage of amitriptylineimipramine.
* Start low, go slow.}}
