Difference between revisions of "Combining-Lamotrigine-Topiramate"
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{{Drugcombi | {{Drugcombi | ||
| − | | base = | + | | base = lamotrigine |
| − | | add = | + | | add = topiramate |
| info = | | info = | ||
* Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases. | * Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases. | ||
| − | * Topiramate induces CYP3A4 and is an | + | * Topiramate induces CYP3A4 and is an inhibitor of CYP2C19. |
| start = | | start = | ||
* Topiramate does not cause a significant change in lamotrigine levels. Start topiramate according to the general dosing advice. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> | * Topiramate does not cause a significant change in lamotrigine levels. Start topiramate according to the general dosing advice. <ref> {{Pubmed|12180999|Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23}}</ref> | ||
| cave = | | cave = | ||
}} | }} | ||
Revision as of 14:32, 4 March 2010
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Adding topiramate to lamotrigine.
General information- Lamotrigine is principally metabolised by UDP-glucuronosyltransferases.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
- Lamoptrigine is principally metabolised by UDP-glucuronosyltransferases.
- Topiramate induces CYP3A4 and is an inhibitor of CYP2C19.
Start topiramate- Topiramate does not cause a significant change in lamotrigine levels. Start topiramate according to the general dosing advice. [4]
- ↑ Farmacotherapeutisch Kompas; Toxicologie (dutch)
- ↑ 2.0 2.1 2.2 Farmacotherapeutisch Kompas - lamotrigine (dutch)
Cite error: Invalid
<ref>tag; name "ftk" defined multiple times with different content Cite error: Invalid<ref>tag; name "ftk" defined multiple times with different content - ↑ Drugs.com lamotrigine
- ↑ Berry at al, Lack of an effect of topiramate on lamotrigine serum concentrations. Epilepsia 2002;43(8):818-23
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