Difference between revisions of "Combining-Carbamazepine-Olanzapine"
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* Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref> | * Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. <ref> {{Pubmed|9860152|Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43}}</ref> | ||
* Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref><ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> | * Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. <ref name=”medicatiebewaking”> Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002. </ref><ref name=”bazire”> Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007. </ref> | ||
| − | | cave = <ref>{{drugscominteract| | + | | cave = <ref>{{drugscominteract|carbamazepine-with-zyprexa-497-0-1744-1113|carbamazepine|olanzapine}}</ref> |
}} | }} | ||
Revision as of 20:01, 4 March 2010
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Adding olanzapine to carbamazepine.
General information- Carbamazepine is principally metabolized by CYP3A4, and is a potent inducer of CYP1A2, CYP2C9, CYP3A4 and UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
- Carbamazepine is principally metabolized by CYP3A4 (also CYP2C8), but is also a potent inducer of CYP1A2, CYP3A4 and UDP-glucuronosyltransferases.
- Olanzapine is principally metabolized by CYP1A2 and CYP2D6.
Start olanzapine- Carbamazepine can reduce olanzapine serum concentration, possible below therapeutic range. [6]
- Add olanzapine according to the general dosing advice and increase dose based on clinical effect or serum concentration. [7][8]
Cave
- ↑ WHO Collaborating Centre for Drug Statistics Methodology ATC=N03AF01
- ↑ 2.0 2.1 Farmacotherapeutisch Kompas; Toxicologie (dutch)
Cite error: Invalid
<ref>tag; name "ftktox" defined multiple times with different content - ↑ Farmacotherapeutisch Kompas - carbamazepine (dutch)
- ↑ 4.0 4.1 4.2 4.3 4.4 KNMP; Informatorium Medicamentorum 2023; Monografie "carbamazepine" (Dutch)
Cite error: Invalid
<ref>tag; name "informatorium" defined multiple times with different content - ↑ Woods SW Chlorpromazine equivalent doses for the newer atypical antipsychotics; J Clin Psychiatry 2003;64:663-667
- ↑ Lucas RA et al. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur J Clin Pharmacol 1998;54:639-43
- ↑ Schalekamp T. et al, Interacties met Psychofarmaca, Stichting Health Base, Houten, 2002.
- ↑ Bazire S, Pshychotropic Drug Directory 2007, HealthComm UK Limited, Aberdeen, 2007.
- ↑ Interactions between carbamazepine and olanzapine on drugs.com
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