Difference between revisions of "Escitalopram-tranylcypromine"
From Psychiatrienet
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| − | + | {{Drugswitch | |
| + | | from = escitalopram | ||
| + | | to = tranylcypromine | ||
| + | | stop = {{StopEscitalopram}} | ||
| + | | start = | ||
| + | * '''Day 8-21:''' a wash-out period of two weeks is necessary. | ||
| + | * '''Day 22:''' Start administration of tranylcypromine in low dosage of 20 mg/day for one week. | ||
| + | * '''Day 29:''' after this week the dosage of tranylcypromine can be increased if necessary. | ||
| + | | caveat = | ||
| + | * Occurrence of serotonin syndrome is reported when a wash-out period (of two weeks) is not considered. | ||
| + | }} | ||
Revision as of 21:44, 4 March 2010
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Switch medication from escitalopram to tranylcypromine.[1] [2]
Stop escitalopram - Before day 1: gradually reduce dosage of escitalopram to a maximum of 10 mg/day, when this dosage is >10 mg/day.
- Day 1: reduce dosage of escitalopram to a maximum of 5 mg/day.
- Day 8: stop administration of escitalopram.
Start tranylcypromine- Day 8-21: a wash-out period of two weeks is necessary.
- Day 22: Start administration of tranylcypromine in low dosage of 20 mg/day for one week.
- Day 29: after this week the dosage of tranylcypromine can be increased if necessary.
Cave- Occurrence of serotonin syndrome is reported when a wash-out period (of two weeks) is not considered.
- ↑ Switches are based on literature references on this page and expert opinions of the authors. The authors have used pharmacokinetic and receptor affinity properties to determine the switch schedules
- ↑ Stahl, S. M. (2013). Stahl's essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). Cambridge University Press.
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